Diabetes pilot review12/12/2022 ![]() HbA1c and sensor glucose downloads were obtained quarterly. Forty-two adolescents, 21 per group, underwent cognitive assessment and multi-modal brain imaging before and after the six month study duration. ![]() Research staff scoring the cognitive assessments as well as those processing imaging data were blinded to group status though participants and their families were not. Participant data were collected across five academic medical centers in the United States. Two randomized participants failed to complete baseline assessments and were excluded from final analyses. Of 46 participants assessed for eligibility, 44 met criteria and were randomized. Randomization to either a hybrid closed-loop or standard diabetes care group was performed after pre-qualification, consent, enrollment, and collection of medical background information. Eligibility criteria for participation in the study included age between 14 and 17 years and a diagnosis of T1D before 8 years of age. This proof-of-concept pilot study ( Identifier NCT03428932) examined whether MRI-derived indices of brain development and function and standardized IQ scores in adolescents with T1D could be improved with better diabetes control using a hybrid closed-loop insulin delivery system. ![]() Type 1 diabetes (T1D) is associated with lower scores on tests of cognitive and neuropsychological function and alterations in brain structure and function in children. ![]()
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